RESUMO
Heritable diseases associated with childhood tumors are sometimes defined as a probable etiologic factor or a coincidence. First of all, we must know the actual number of patients. Herein a case with medulloblastoma associated with glutaric aciduria type II [corrected] is reported for this purpose. A 5-year-old boy was admitted with nausea, vomiting, and lethargy. In medical history, consanguinity and siblings with mental-motor retardation and epilepsy are remarkable. Growth retardation, macrocephaly, lethargy, tremor, bilateral nistagmus, and papilledema were prominent features in physical examination. Noncontrast computed tomography of the brain showed a hyper dense mass in the cerebellar vermis. Gross total resection was made and the histopathology of the tumor was medulloblastoma. Besides medical history and physical findings, radiologic white matter changes in the subcortical, periventricular regions, bilateral basal ganglia, and caudate nuclei in magnetic resonance images other than tumor led us to investigate the child for glutaric aciduria type II [corrected]. The level of the 2-OH glutaric acid was determined as being 12-fold high in the urine. Chemo-radiotherapy was performed after surgery. Our case was the third patient with medulloblastoma in the literature and is still alive with no evidence of the disease 19 months after the initial diagnosis.
Assuntos
Neoplasias Cerebelares/diagnóstico por imagem , Neoplasias Cerebelares/terapia , Meduloblastoma/diagnóstico por imagem , Meduloblastoma/terapia , Deficiência Múltipla de Acil Coenzima A Desidrogenase/diagnóstico por imagem , Deficiência Múltipla de Acil Coenzima A Desidrogenase/terapia , Neoplasias Cerebelares/urina , Pré-Escolar , Glutamatos/urina , Humanos , Masculino , Meduloblastoma/urina , Deficiência Múltipla de Acil Coenzima A Desidrogenase/urina , RadiografiaRESUMO
Mongrel adult albino female rats with multiform glioblastoma transplanted to the right cerebellar hemisphere were given subcutaneous injections of 8 mg/kg of a serotonin-creatine sulphate solution beginning with the 3rd and to the 28th postoperative days. Rats with a tumor inoculated at the same periods and given injections of a physiological saline solution served as controls. The injection of serotonin leads to a significant increase in the survival of rats by 20% as compared to the survival of rats in the control group, but practically has no effect on the life span of sick animals. Consequently, serotonin either produces an antineoplastic effect in which case the animals do not contract the disease, or it has no effect on the tumor so that the animals die of the developing tumor. Study of the tryptophan content in the neoplasm and the 5-OIAA content in urine provides evidence of a disturbed serotonin synthesis and metabolism in these neoplasms.
Assuntos
Antineoplásicos , Neoplasias Cerebelares/tratamento farmacológico , Glioblastoma/tratamento farmacológico , Serotonina/uso terapêutico , Animais , Neoplasias Cerebelares/urina , Feminino , Glioblastoma/urina , Ácido Hidroxi-Indolacético/urina , Transplante de Neoplasias , Neoplasias Experimentais , RatosRESUMO
The metabolities of biogenic amines were determined in the 24-hour urine samples of patients submitted to surgical removal of a malignant brain tumour and subsequently to telecobalt therapy of the corresponding head region. A significant increase in the excretion of 5-hydroxyindoleacetic acid (5-HIAA), vanillinmandelic acid (VMA) as well as of free 3-methoxy-4-hydroxy-phenylglycol (MHPG) during the period of irradiation was found. This increase is presumably the result of radiation induced release of their parent amines from the brain; in the case of VMA the secondary response of the peripheral sympathetic system might occur.
Assuntos
Neoplasias Encefálicas/urina , Glicóis/urina , Ácido Hidroxi-Indolacético/urina , Metoxi-Hidroxifenilglicol/urina , Ácido Vanilmandélico/urina , Adenoma/urina , Adolescente , Adulto , Idoso , Neoplasias Encefálicas/radioterapia , Neoplasias Cerebelares/urina , Criança , Creatinina/urina , Feminino , Glioma/urina , Humanos , Linfoma Difuso de Grandes Células B/urina , Masculino , Meduloblastoma/urina , Pessoa de Meia-Idade , Oligodendroglioma/urina , Neoplasias Hipofisárias/urina , Sarcoma/urinaRESUMO
Cerebrospinal fluid (CSF) concentration and urinary excretion of cyclic adenosine-3',5'-monophosphate(cAMP) were measured in children aged from 3 days to 15 years by the protein-binding method of Gilman (1970). The mean CSF cAMP concentration (22.4 plus or minus 0.6 (S.E.) nmol/l) of 24 "healthy" children tended to be lower (P less then 0.2) than that of adult patients who revealed no pathological findings on clinical examination. No difference in the results was foung between the sexes. High cAMP concentrations were found in CSF of children suffering from cerebellar glioma, hypothalamic precocious puberty, bacterial meningitis, or Cushing's disease. The urinary excretion of cAMP varied from 0.2 to 5.3 in "healthy" and from 1.3 to 7.6 mumol/24 hrs in diseased children. Two children with pheochromocytoma showed a striking decrease in the rate of urinary excretion of the nucleotide after surgical treatment.